Older patients may
be more likely to die in the hospital following the implantation of
defibrillators or pacemakers, according to a report in the April 12 issue of Archives
of Internal Medicine, one of the
JAMA/Archives journals. More than one-fifth of cardiac devices appear to be
implanted in individuals age 80 and older, despite the fact that most clinical
trials have not included adults in this age group.
"Implantable
cardiac devices have been increasingly used in primary prevention of sudden
cardiac death among patients with systolic heart failure, largely on the basis
of favorable results from large multicenter clinical trials," the authors
write as background information in the article. One such device is an
implantable cardioverter defibrillator, which monitors the heart's rhythm and
delivers electrical shocks if needed to restore normal heart function.
Defibrillators or pacemakers are often used to coordinate the actions of the
heart's ventricles in a procedure known as cardiac resynchronization therapy.
"However, it
has become increasingly apparent that certain patient subgroups may not benefit
from device implantation; for example, use of implantable cardiac
defibrillators in patients with renal failure and in those with advanced heart
failure symptoms has not been associated with a survival benefit," the
authors write. Because the average age in major clinical trials has ranged from
58 to 67 years and some have specified an upper age limit of 80 years, limited
data are available on the use of these devices in older adults.
Jason P. Swindle,
M.P.H., then of Saint Louis University School of Medicine, and colleagues
analyzed data from 26,887 adults who were hospitalized with a diagnosis of
heart failure and underwent implantation of a defibrillator or cardiac
resynchronization therapy in 2004 or 2005.
The median
(midpoint) age of all patients was 70 years. Patients age 80 and older
accounted for 17.5 percent of the procedures (4,694 patients), including 992
patients (21.1 percent) who were older than 85 years and 309 patients (6.6
percent) who were 89 years or older. In-hospital death rates increased from 0.7
percent among patients younger than 80 years to 1.2 percent among those age 80
to 85 and 2.2 percent among those older than 85 years.
"We found that
older patients were less likely to have a concomitant cardiac procedure or a
high comorbidity score, suggesting that these patients may be, in fact,
somewhat more carefully selected than the younger cohort," the authors
write. "However, older patients had slightly more complications related to
the device procedure."
"Given trends
in the demographics of heart failure and the costs of device therapy,
additional studies are required to clarify the appropriateness of device
implantation in older patients with heart failure, as well as the merits of
less invasive options," they conclude.
SOURCE: Arch Intern Med.
2010;170[7]:631-637.